½ÒÏþÔÚ2ÔÂ1ÈÕ¡¶Nature¡·ÉϵÄÒ»Ïî»ùÓÚСÊóµÄÑо¿Åú×¢£¨µã»÷×óϽÇÔĶÁÔÎÄ£©£¬Ê³ÓÃÊ®×Ö»¨¿ÆÊ߲ˣ¨°üÀ¨Î÷À¼»¨¡¢¸ÊÀ¶ºÍ»¨Ò¬²ËµÈ£©Äܹ»×ÊÖúÃâÒßϵͳ¶Ô¿¹³¦µÀ²¡ÔÌå¡£¸ÃÑо¿¶Ô»¼ÓÐÑ×Ö¢ÐÔ³¦µÀ¼²²¡µÄ»¼Õß¾ßÓÐÖ÷ÒªÒâÒå¡£
Ò»ÖÖÃûΪ·¼ÌþÊÜÌå (AhR) µÄÂѰ×ÖÊÔÚ±£»¤ÎÒÃDz»ÊÜÍâ½çÎÛȾÎï¡¢¶¾ÎïºÍ²¡ÔÌåµÈµÄΣÏÕ·½ÃæÊÎÑÝ×ÅÖ÷Òª½ÇÉ«£¬ËüÔÚÎÒÃÇµÄÆ¤·ô¡¢·Î²¿¡¢³¦µÀÖÐÆðµ½ÆÁÕÏ×÷Óá£
ͨ¹ýÑо¿AhRÔÚ³¦µÀÄÚµÄ×÷Óã¬Ó¢¹ú¸¥ÀÊÎ÷˹-¿ËÀï¿Ë£¨Francis Crick£©Ñо¿ËùµÄ¿ÆÑ§¼Ò·¢Ã÷£¬ÁíÒ»ÖÖÃûΪCyp1a1µÄÂѰ×ÖÊÄܹ»µ÷Àí³¦µÀµÄÃâÒßÁ¦£¬Í¨¹ý½«AhRÅäÌå½µ½âµÄ·½·¨ÌṩÓëAhRÐźÅÏà¹ØµÄ·´Ïì¡£
È»¶ø£¬¹ý¶àµÄCyp1a1»áºÄ¾¡AhRÅäÌå¡£Õ⽫»áµ¼Ö»úÌåÒ×ÊÜϸ¾ú£¨ºÃ±È´ó³¦¸Ë¾úµÈ²¡ÔÌ壩ѬȾ£¬Ò²¿ÉÄÜÔÚÑ×Ö¢ÐÔ³¦µÀ¼²²¡ÖÐʩչÖ÷Òª×÷Óá£
ÕâÏîÑо¿ÊÂÇéµÄÏòµ¼ÕßStockinger²©Ê¿Ëµ£º“ÎÒÃÇÒѾ֪µÀ£¬AhRµÄȱ·¦»áΪ³¦µÀÆÁÕÏ´øÀ´¶àÖÖÎÊÌâ¡£ÕâÊÇÓÉÓÚ±£»¤ÎÒÃÇÃâÊܳ¦µÀϸ¾úºÍÍâÀ´²¡ÔÌåË𺦵ÄÃâÒßϸ°ûÐèҪͨ¹ýAhR»ñµÃÐźÅÀ´Î¬³ÖÉúÑÄ¡£¼¤»îAhRµÄ·Ö×ӼȿÉÄÜȪԴÓÚÒûʳ£¬Ò²¿ÉÄÜȪԴÓÚ³¦µÀϸ¾ú¡£AhRµÄ¼¤»î»á¿ªÆôÖîÈçCyp1a1µÈøÀàµÄ±í´ï¡£Í¨³££¬ÕâЩøµÄ¹¦Ð§Êǽµ½â×î³õ¼¤»îAhRµÄ·Ö×Ó£¬²¢¹Ø±ÕÆä±í´ï¡£”
Ñо¿Ö°Ô±¹¹½¨ÁËÓµÓÐÌ«¹ý±í´ïµÄCyp1a1СÊóÄ£×Ó£¬Õâ»áºÄ¾¡Ð¡ÊóµÄAhRÅäÌå²¢µ¼ÖÂÒÀÀµAhRÅäÌåµÄÃâÒßϸ°ûÊýÄ¿ïÔÌ¡£ÓëÕý³£µÄ¿µ½¡Ð¡Êó²î±ð£¬ÕâЩСÊóÎÞ·¨¶Ô¿¹ÄûÃÊËá¸Ë¾úµÄѬȾ£¬ÕâÖÖϸ¾ú¹ØÓÚСÊóÀ´ËµÏ൱ÓÚÈËÀàµÄ´ó³¦¸Ë¾ú¡£Ö÷ÒªµÄÊÇ£¬ÏòСÊóÒûʳÖÐÌí¼ÓÊ®×Ö»¨¿ÆÊß²ËÖеÄÓªÑøÒòËØÄܹ»ÓÐÓÿØÖÆCyp1a1»îÐÔµÄÔöÌí¡£ËüÊÇͨ¹ýÁ½ÖÖ·½·¨Æð×÷Ó㬼´ÒÖÖÆCyp1a1ºÍÌá¹©ÌØÁíÍâAhR¼¤»î·Ö×Ó¡£
Stockinger²©Ê¿Ëµ£º“ÒÑÍùµÄÑо¿ÊÂÇé´ó²¿·Ö¶¼¹Ø×¢AhRÔÚ¶àÀàÐÍϸ°ûÖÐÍêȫȱʧÔì³ÉµÄЧ¹û£¬µ«Õâ²¢²»ÊÇÊÊÓÃÓÚÈËÀà»úÌåµÄÇéÐΣ¬ÓÉÓÚAhRȱ·¦ÔÚ²î±ðÉúÃüÐÎʽÖеÄÌåÏÖ²¢·×ÆçÖ¡£ÎÒÃǵÄÑо¿Åú×¢£¬Ä³Ð©È˾ßÓÐÍ»±äµÄCyp1a1ø£¬ÕâЩøÒì³£»îÔ¾¡£¹ØÓÚÈËÀàÀ´Ëµ£¬Cyp1a1øÔÚѬȾÐÔ³¦µÀ¼²²¡ÖÐÆð×÷Óã¬Ä³Ð©ÌìÉúCyp1a1ø¾ÍÌ«¹ý»îÔ¾µÄÈËÓÈÆäÈÝÒ×Êܵ½Ñ¬È¾¡£ÕâЩÈË¿ÉÒÔͨ¹ýʳÓÃÊ®×Ö»¨¿ÆÊß²ËÀ´¸ÄÉÆ³¦µÀÃâÒß¹¦Ð§£¬ºÃ±ÈÎ÷À¼»¨¡¢¸ÊÀ¶¡¢»¨Ò¬²ËºÍ½æÀ¶µÈ£¬ËüÃǸ»º¬Cyp1a1ÒÖÖÆÒò×ÓÒÔ¼°¼¤»îAhRµÄ·Ö×Ó¡£”